It means there is not a valid connection path from your computer to the ip address and port. This can be caused by:

* The ip address is not reachable from your computer, e.g. because it is on a different network or if firewalls are preventing the traffic.

* MySQL is not running on that ip or on that port. Or, if it is, it might only accept connections on the same machine (localhost).

You can verify this from the command line on your computer. Try to establish a connection using the mysql command line client instead:

mysql -uroot -pPASSWORD -h IPADDRESS -P 3306

You can also try to ping the ip and see if it is responds. But ping does not always return responses, so it might not work:

ping IPADDRESS

I'm guessing 80.249.173.141 is a host on the public internet, not on a private network. In that case, your ISP is probably blocking external MySQL access for security reasons. You would probably only be able to connect to MySQL by first logging in to the machine using SSH, and then connecting to mysql from the command line on the same machine.

One way to get Jet Profiler to connect to it would then be to establish and ssh tunnel, see this post:

http://www.jetprofiler.com/forum/discussion/8/mysql-ssh-tunnel/

You can also contact your ISP to get more information on how to connect.

I typed the following command :
ssh -N -f -L 3307:localhost:3306 root@80.249.173.141

and for me it says:
bind: Address already in use
channel_setup_fwd_listener: cannot listen to port: 3307
Could not request local forwarding.

What now ? :|

do you have any idea why my website crashed?

Unable to establish connection to MySQL
1045 : Access denied for user 'www-data'@'localhost' (using password: NO)

i got the problem solved,the user rights were changed from local to 80.249.173.141.This was the problem.